http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RO-81387-B

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filingDate 1981-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1983-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RO-81387-B
titleOfInvention PROCESS FOR THE PREPARATION OF ESCHERICHIA COLI THERMOSTABLE THERAPEUTIC DERIVATIVES
abstract The process consists in preparing a thermostable enterotoxin derivative of Escherichia coli consisting of the reaction of ST enterotoxin ST from Escherichia coli ATCC 31621 with a non-toxic bifunctional reticular glutaraldehyde agent, 1-Ethyl-3- (3-dimethylaminopropyl) -carbodiimide, difluoronitrobenzene, the temperature below 37 ° C preferably 20 ... 25 ° C in an aqueous medium and preferably buffered at a pH between 4 and 8.
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