| abstract |
Process for the preparation of corticoids of general formula I: (see formula) wherein n represents 2 or 3, x represents hydrogen, chlorine or fluorine, Y represents alkali metal or N-methyl glucamine, characterized in that a compound of formula is treated general II: (see formula) wherein X has the meaning shown above, with succinic acid anhydride or glutamic acid anhydride in weight ratio of 1 ... 2,5: 0.5 ... 1 at boiling temperature of the reaction mixture using as a pyridine solvent, then the process is converted to alkali metal salt, or N-methylglucamine salt, as known. |