| abstract |
The invention relates to a process for the preparation of N, N -dimethyl-N '- (4-L-leucylaminophenyl) -acetamidines, which comprises reacting N- (t-butyloxycarbonyl) -L- (N-hydroxysuccinimide) with N '- (4-aminophenyl) -N, N-dimethylacetamidine in a molar ratio of about 1: 1 at 0-5 ° C in absolute tetrahydrofuran medium, then stirring for about 12 hours at room temperature, then evaporated to dryness in trifluoroacetic acid and held for about 1/2 hour at room temperature, then the mixture is worked up in order to separate the reaction product. |