http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RO-134900-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_180468133d4b41a5b7420f0a1d8c0d8e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-005 |
| filingDate | 2019-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a33375ce33ec815ae0e792a1ff772f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c14a2955a83fdf98a0e6abbb3f5ed69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c5ebdc7e513c8a2767a6cd5699e879e |
| publicationDate | 2021-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RO-134900-A2 |
| titleOfInvention | BIOLOGICAL SYSTEM BASED ON AN ANTI-TUMOR HYBRID VIRAL VECTOR FOR THE RESTORATION OF THE NORMAL GENOTYPE OF THE TP 53 TUMOR SUPPRESSOR GENE IN MALIGNANT CELLS |
| abstract | The invention belongs to the biomedical field and relates to a hybrid system derived from bacterial viruses, with the property of targeting tumor cells and restoring the normal function of the p53 protein, thus inducing apoptosis in transduced cells. The vector system based on the bacteriophage M13, according to the invention, is modified at the capsid level by genetic engineering techniques with cyclic tripeptide of the RDG motif binding to overexpressed integrins on tumor cells. The genetic elements necessary to restore the normal function of the p53 protein by CRISP / Cas9 genomic editing are cloned in the form of 4 expression cassettes with high tumor specificity. These genetic elements will lead to the replacement of the TP53 mutant gene in tumor cells with a cassette expressing a functional copy of TP53. By induction with doxycycline, this copy is transcribed and translated into the active p53 protein, which will exert its pro-apoptotic and anti-proliferative effect. A schematic representation of the operating principle of the vector system of the invention is found in FIG. 1. |
| priorityDate | 2019-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.