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filingDate 1998-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17483811537da832947da9a470a04c05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79e838f0b3ee328bbd342bc792ff3d8d
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publicationDate 2006-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RO-120602-B1
titleOfInvention PHARMACEUTICAL COMPOSITION FOR THE CONTROLLED ELEMENTS OF THE ACTIVE SUBSTANCES AND THE PROCEDURE FOR PREPARING THEM
abstract The invention relates to a pharmaceutical composition for the controlled release of the active substances and to a process for its preparation. A pharmaceutical composition for controlled release of substances, comprising at least one excipient selected from inert matrix, hydrophilic matrix, lipid matrix, inert matrix mixture and lipid matrix, hydrophilic matrix and inert matrix mixtures, except for mixtures comprising polyacrylic acid and at least one hydrophilic cellulose type matrix and between 5 and 50% by weight, relative to the total weight of the composition, of at least one soluble alkalizing agent in an aqueous phase, under physiological pH conditions, selected from hydroxides, carbonates, alkali or alkaline earth metal bicarbonates and phosphates, sodium borate, as well as basic salts of organic acids, optionally one or more pharmaceutically acceptable excipients, as well as the process for preparing the composition, comprising the following successive steps: i) preparation of a homogeneous mixture, containing components a, b and c and other exc optionally present patients; ii) tabletting the homogeneous mixture, obtained in step i), optionally after granulation.
priorityDate 1997-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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