| abstract |
The invention relates to the use of a cyclooxygenase-2 inhibitor compound in the treatment and / or prevention of neoplasia. The compound used has the formula (II): wherein R 4 is lower haloalkyl, R 5 is hydrido and R 6 is phenyl, optionally substituted at a substitution position, with one or more radicals selected from halogen, lower alkylthio, lower alkylsulfonyl, cyano, nitro, lower haloalkyl, lower alkyl, hydroxyl, lower alkenyl, lower hydroxyalkyl, carboxyl, lower cycloalkyl, lower alkylamino, lower dialkylamino, alkoxycarbonyl, aminocarbonyl, lower alkoxy, lower haloalkoxy, sulfamyl, 5- or 6-membered heterocycle; or a pharmaceutically acceptable salt thereof, or a derivative thereof, and is used to prepare a drug for the prevention and / or treatment of neoplasia in a subject. |