| abstract |
The invention relates to biopolymer microspheres based on collagen extracted from bovine skins and injectable suspensions copolymers with applications in controlled release and controlled dosing of biologically active compounds. Microspheres are composite microparticles consisting of 80 ... 95% collagen with an average molecular weight of 150 ... 200 Kda and 5 ... 20% copolymer resulting from copolymerization between maleic anhydride, acrolein or glycidyl methacrylate reactive monomers with comonomers of the type: styrene, ethyl acrylate, methyl methacrylate, methyl methacrylate, ethylene. à |