| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-935 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1029
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-82 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 |
| filingDate |
1992-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc1ab7c4d402b55e675a03120a04be36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0eef94e433531978347b51f12ca01992
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0e8bd20c659d9e04854b328f0dffdde
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7471dc6410b8a3b79d5dc7455cd04466
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f9ef116f024644b65d72a46e52ec180
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_198e537b8141e6f268e1f17a920feec3 |
| publicationDate |
2001-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RO-116648-B1 |
| titleOfInvention |
BIOPROCEDEUM FOR PREPARATION OF 7-AMINO-3-DEACETYL-CEFALOSPORANIC ACID AND 7-AMINOEFALOSPORANIC ACID |
| abstract |
The invention relates to a bioprocess for the preparation of 7-amino-3-deacetyl-cephalosporanic acid and 7-aminocephalosporanic acid, adipic acid or one or more of its salts and esters, which have the capacity to be assimilated and used by Penicillium chrysogenum strain to produce adipoyl-6-amino-penicillanic acid followed by transformation of a strain of Penicillium chrysogenum with a gene coding for a expandase enzyme derived from Cephalosporium acremonium, which will in turn convert adipoyl -6-amino-penicillanic acid in adipoyl adipoyl 7-amino-deacetoxycephalosporanic acid, transforming a strain of Penicillium chrysogenum which produces isopenicillin N with a gene encoding an hydroxylase enzyme derived preferably from Cephalosporium acremonium which will convert in situ adipoyl-7-amino-deacetoxycephalosporanic acid in adipoyl 7-amino-deacetylcephalosporanic acid, which will undergo further enzymatic transformation to obtain 7-amino-3-deacetyl-cephalosporanic acid and 7-aminocephalosporanic acid. |
| priorityDate |
1991-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |