| abstract |
The present invention relates to a process for obtaining water-soluble micronized substances which, in order to obtain particles smaller than 100 μm, which can be produced, stored and used, maintaining the aerodynamic properties required for inhalation of such of the substances comprises the following steps: a) reduction, if necessary, of the waste water of the micronised substance, by optional drying at a high temperature and / or from: b) conditioning of the dried, dry substances with a solvent selected from organic alcohols, ketones , esters, acetonitrile or other pharmaceutically acceptable solvents, preferably in the vapor phase or in an inert gas containing solvent vapors, optionally gas is nitrogen; and c) removing the residual solvent by storing in a dry place, such as vacuum or by purging with an inert gas, which optionally is nitrogen. |