http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PT-99471-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69c91bbf0395db010b4806f50d808c4e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-00 |
| filingDate | 1991-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b168345eb9b26e7ae5d3b6b9e4bbb2d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ebc4c0d70a583d5933b359932d756cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6c8ed0c612311fbf15e952aace8df9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_604b98ba85c3f32c8f7c666da036dca9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1baf7d1022cd370671106035361f8b2b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a7cbfc800cbb719bcf5cc3f16dae24d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b90f29bfc0690eaf24439d3b02739f1d |
| publicationDate | 1999-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PT-99471-B |
| titleOfInvention | 1-BETA-ETHYL-1-ALF- (HYDROXYMETHYL) -1,2,3,4,6,7,12,12B-ALPHA-OCTAHYDRO-INDOLE (2,3, -A } -CHINOLIZIN AND INTERMEDIATE COMPOUNDS |
| abstract | The invention relates to a process for the preparation of (-)-1beta-ethyl-1alpha-(hydroxymethyl)-1,2,3,4,6,7,12,12b alpha-octahydroindole [2,3-a]-quinolizine of formula I <IMAGE> by reacting 1-ethyl-2,3,4,6,7,12-hexahydroindole [2,3-a]- quinolizine of formula II <IMAGE> with an approximately equimolar quantity of formaldehyde or a polymerized form of the latter and, after isolation, if desired, treating the racemic 1-ethyl-(hydroxymethyl)- 1,2,3,4,6,7-hexahydro-12H-indole [2,3-a]-quinolizine compound of formula III <IMAGE> with a resolving agent in a quantity less than an equimolar quantity, and reducing the 1beta-ethyl-1alpha- (hydroxymethyl)-1,2,3,4,6,7-hexahydro-12H-indole-[2,3-a]- quinolizine-5 salt of formula IV <IMAGE> in which X- represents the radical of an optically active acid, and, if desired, releasing the free base of formula I. The intermediate compounds of formulae III, IV and V are also new, so their processes of preparation are also included in this invention. The compound of formula I has peripheral vasodilatory properties. |
| priorityDate | 1991-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.