| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0f4246e8fcebf17c365aced017a04c61 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-22 |
| filingDate |
1991-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6def67a083ec8bed6af3a06d50c5e01d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8857da1328a894136a42f4e3da44b9b9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df59c625e4b46851433b11bfe3c28521 |
| publicationDate |
1993-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
PT-99297-A |
| titleOfInvention |
PREPARATION PROCESS OF REDUCED CAMPTOTECINS |
| abstract |
The present invention relates to the process for preparation of a reduced camptothecin derivative which involves hydrolysing a camptothecin substrate under alkaline conditions with a reducible substituent, in order to open the lactone E ring and form a carboxylate salt. The carboxylate salt is reduced in order to form a reduced carboxylate salt which is then brought into contact with acid for restoration of the lactone E ring. This process results in substantially increased yields in the camptothecin derivatives. |
| priorityDate |
1991-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |