| abstract |
Piperazinoalkyl carboxamides of formula (I), their salts, optical, and geometric isomes, are new. in (I) A = 1-2C alkylene, (opt. substd by 1 or more 1-6C alkyl); R=H or 1-6C alkyl; R1=6-12C mono- or bi- cyclic aryl, or heteroaryl; R2 = as R1 or aryl- or heteroaryl- 1-6C alkyl; R3 = H, 1-6C alkyl, or 6-12C aryl; and R4 = H, 1-6C alkyl, 3-12C cycloalkyl, 3-12C cycloalkyl 1-6C alkyl, 6-12C aryl, or 6-12C aryl 1-6C alkyl; or NR3R4 together = a satd. heterocyclic ring, opt. contg. a further atom; and the dotted line = an opt. bond, in which case the bracketed H atoms are absent. |