| abstract |
This invention relates to the use of tenidap, 5-chloro-2,3-dihydro-2-oxo-3-(2-thienylcarbonyl)-indole-1-carboxamide, for the manufacture of a composition for inhibiting the activation of collagenase in a mammal and for inhibiting the activity of myeloperoxidase in a mammal. This invention also relates to the use of tenidap and its salts for the manufacture of a medicament for treating collagenase mediated disorders and diseases such as bone resorption disorders, corneal ulceration, periodontal disease, inflammatory disease and wounds of the skin and burns in mammals. |