http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PT-97005-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef2e9f5ce8630d9b282043b8d060caff |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 1991-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a62d9e27a534a44dc3ec8cb4aad4a07 |
| publicationDate | 1998-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PT-97005-B |
| titleOfInvention | PREPARATION PROCESS FOR (2-IMIDAZOLIN-2-ILAMINO) TETRAHYDROQUINOXALINS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| abstract | This invention relates to a process for the preparation of a compound having the formula <IMAGE> in which R1 and R4 are selected, independently of each other, from a group comprising H and alkyl radicals containing 1 to 4 carbon atoms. R2 and R3 are selected independently of each other from a group comprising H, O and alkyl radicals containing 1 to 4 carbon atoms, the 2-imidazolin-2-ylamino group may be in any one of the 5-, 6-, 7- or 3- positions of the quinoxaline nucleus, and each of the R5, R6 and R7 is located in one of the remaining 5-, 6-, 7- or 8- positions in the quinoxaline nucleus and is selected independently of the others from the group comprising Cl, Br, H and alkyl radicals containing 1 to 3 carbon atoms, and their pharmaceutically acceptable acid addition salts. The process comprises the saturation of any unsaturations in the 1-, 2-, 3- or 4-positions of the quinoxaline nucleus of a corresponding (2-imidazoline-2- ylamino)quinoxaline compound, separation of the product produced from the reaction mixture, its recovery and if necessary its formation into a salt. The invention also relates to a process for preparing pharmaceutical compositions containing those compounds. When administered to a mammal the compounds prepared provide desired therapeutic effects such as changes in the rate of transport of fluid in the gastrointestinal tract, reduction in intraocular pressure and an increase in kidney fluid flow. |
| priorityDate | 1991-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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