| abstract |
The invention concerns a heterocyclic derivative of the formula I,n wherein Ar¹ is optionally substituted phenyl or naphthyl; nA¹ is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo-(3-6C)alkylene; nAr² is optionally substituted phenylene, or a 6 membered heterocyclene moiety containing up to three nitrogen atoms; nR¹ is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and nR² and R³ together form a group of the formula -A²-X-A³- wherein each of A² and A³ is (1-4C)alkylene and X is oxy, thio, sulphinyl, sulphonyl or imino; nor a pharmaceutically-acceptable salt thereof. n The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase. |