| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36b5c496f6aec894819ec2acaedb4203 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-99009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0095
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01053
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-15004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y118-01002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y106-02004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-15006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P33-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-85 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-04 |
| filingDate |
1989-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2453014bce881790c9ece3fcec2614aa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b95733504af849238d22d431653a078
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3096d6ad376bb9e89541ae899b493b0d |
| publicationDate |
1996-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
PT-92543-B |
| titleOfInvention |
PROCESS FOR MULTIPLE OXIDATION OF STEROIDS AND FOR THE OBTAINING OF CELLS BY GENETIC ENGINEERING TO BE USED IN THEIR REALIZATION |
| abstract |
Genetically engineered host cells are provided which are able to carry out simultaneously oxidations of steroids, preferably the simultaneous introduction of the 17 alpha -hydroxyl and the C21-hydroxyl group. In particular the oxidation is carried out with cells into which DNA has been introduced which encodes for at least two proteins involved in the biological pathway of cholesterol to hydrocortisone. Suited host cells comprise species of Bacillus, Saccharomyces or Kluyveromyces. The new host cells are suited for biochemical oxidations of cholesterol, pregnenolone, progesterone and 17 alpha -hydroxy-progesterone, which are intermediates in said biological pathway. The host cells are also useful for the ultimate preparation of a multigenic system for the one-step conversion of cholesterol into hydrocortisone. |
| priorityDate |
1988-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |