| abstract |
Pharmaceutical thiazolo-[1,5]benzodiazepines of the formulan in which R¹, R², R³ and R⁴ are independently hydrogen, C₁₋₄ alkyl, C₂₋₄ alkenyl, halogen, C₁₋₄ haloalkyl, nitro, C₁₋₄ alkoxy, C₁₋₄ haloalkoxy, C₁₋₄ alkylthio or phenylsulphonyl; in which R⁵ is a group of the formula formulan where R⁷ is hydrogen, C₁₋₆ alkyl, C₃₋₇ cycloalkyl C₁₋₄ alkyl, benzyl or ZO-C₂₋₆ alkyl where Z is hydrogen or an acyl group, R⁸ is hydrogen or C₁₋₄ alkyl and n is 0 or 1, provided that when R⁷ is hydrogen n is 0; in which R⁶ is hydrogen, C₁₋₁₀ alkyl, C₃₋₇ cycloalkyl, C₃₋₇ cycloalkyl C₁₋₄ alkyl, C₁₋₄ haloalkyl, C₁₋₄ alkoxy or C₁₋₄ alkylthio; and in whichn represents a thiazole ring selected fromn and acid addition salts thereof. n The compounds have central nervous system activity. |