| abstract |
(A) n-Octyl 2-alanyl-2-azabicyclo (3,3,0)octane-3- carboxylate derivs. of formula (Ia), in which all five chiral C atoms are in the S configuration, and their salts are new: R'2 = H or Et; R'3 = n-octyl. (B) Intermediates of formula (IX) and (X) in all-S isomer form are also new (see 'Preparation'). (C) ACE inhibitors (I) are used to prepare medicaments with psychotropic, esp. anxiolytic, activity. Pref (I) have min effective doses of 0.1-30 mg/kg in the 'lick-shock' and 'Geller-Seifter' conflict tests. |