| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a09fa84c54c24536575f7f12c1f1db43 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-755
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-755
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate |
1988-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c97c18486345fb3096d4821c8fa67212
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b41a8adab75d09a0dca76b6fcff3880
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1eda9f63c6d9f39d37afb0219b43b14f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5112a0b05b8e784f2c4dfb590c25c4fa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46ff32161359074f223ca18f37f5f9e9 |
| publicationDate |
1992-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
PT-87752-B |
| titleOfInvention |
PROCESS FOR THE PREPARATION OF A FACTOR VIII: C ANALOGUE MOLECULA WITH COAGULANT ACTIVITY |
| abstract |
A mutant of factor VIII : C in which the amino acids Ser<7><4><1> to Arg<1><6><8><9> are absent from the new molecule consequently retains of the 4 thrombin cleavage sites which have hitherto been regarded as essential only the cleavage site at Arg<3><7><2>. The cleavage site at Arg<1><6><4><8> is absent, and the amino acids adjacent to the cleavage sites at Arg<7><4><0> and Arg<1><6><8><9> are present, and linkage thereof produces a new cleavage site. The protein has a procoagulant activity and biological half-life very similar to that of the authentic protein and, moreover, is more rapidly activated by thrombin. <IMAGE> |
| priorityDate |
1987-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |