http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PT-87366-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-00 |
| filingDate | 1988-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e142de635613eba6b4cd0b1a6ce2d67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a31e66665e48586f5ffe5f16f050d9f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18df591212f639f4cb0db566c78819ae |
| publicationDate | 1994-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PT-87366-B |
| titleOfInvention | PROCESS FOR THE PREPARATION OF 3-ALYL AND 3-BUTYENYL-3-CEFEM DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| abstract | Process is claimed for producing a cephalosporin cpd. having the ceph-3-em nucleus bearing known cephalosporin antibiotic substits. at the 4-, 7- and 8- positions and a -CH2R1 substit. at the 3-position. R= (opt. substd.) vinyl, (opt. substd.) phenyl, 2-, 3- or 4- pyridyl, imidazolyl, 2- thiazolyl, 2- or 3- furyl or 2- thienyl; where the opt. substits. on vinyl and phenyl are chosen from 1-4C alkyl, 1-4C alkoxy, F, Cl, Br and I. The process comprises contacting in a polar aprotic solvent a 3- halomethyl ceph-3-em having substits. at the 4-, 7- and 8-positions which are non-reactive under the reaction conditions with the reagents employed; and (a) at least an equimolar amt. of R1-tri(1-4C alkyl) stannane; (b) 1-10 mol.% of a Pd(O) or Pd(II) cpd.; and (c) 3-30 mole.% of tri(2-furyl) phosphine or tri(2-thienyl) phosphine. Reaction is at 20-75 deg.C for 1-72 hrs. |
| priorityDate | 1988-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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