| abstract |
There are disclosed compounds of the formula <CHEM> wherein R<1> and R<2> are each, independently, hydrogen, hydroxy, lower alkyl, lower alkoxy, haloloweralkyl, haloloweralkyl sulfonyl, halo or nitro; R<3> is hydrogen, lower alkyl, or aryl or 7-12 carbon atoms; <CHEM> A is -CH2-, -O- or -S-; m is 1 - 8; n is 0 - 7, with the proviso that m + n </= 8; or a pharmacologically acceptable salt thereof, and their use as fatty acid oxidation inhibitors possessing a significantly reduced potential for impairment of normal cardiac function, and having particular utility in the treatment of glucose and fatty acid metabolism disorders, such as diabetes. |