| titleOfInvention |
PROCESSES FOR THE PREPARATION OF 2,3,4,5,6,7-HEXAIDRO-2,7-METHANE-1,5-BENZOXAZONINS AND 1,4-BENZOXAZONINS AND OF PHARMACEUTICAL PREPARATIONS THAT CONTAIN THEM |
| abstract |
New 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonine and -1,4-benzoxazonine compounds of the formula <IMAGE> have useful pharmaceutical properites. They are prepared from ketones of the formula <IMAGE> via a lactone intermediate. In the formula, the various R substitutes are generally hydrogen or alkyl, with R4 also being halogen or alkoxy and R3R3' also being phenyl. R1 may be joined with R5/R5' in a 5- to 7-membered ring possibly interrupted by O, S, SO2 or amino. One of X and Y is CH2; the other is amino. The starting ketones also have pharmaceutical properties. The lactone intermediates are new compounds. |