http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PT-83229-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97a285d8ecd0184a7e5d89a1e4e07997 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-36 |
| filingDate | 1986-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6348de18a1c28269d3d51bd8142b7be3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f08ed5e3a333280319a53e741d3bc5f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a356212c89e2ddfddd68926d304907f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a79d989a08027104504db1bb13441f26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b0a0af0d7307103ebd18a3306e752f9 |
| publicationDate | 1986-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PT-83229-A |
| titleOfInvention | Process for the preparation of cephalosporin intermediates |
| abstract | Prepn. of stable, crystalline cephalosporin cpds. of formula (I), free of the delta 2 isomer, comprises treating a cpd. of formula (II) where X = HCl or HI; Z = COOH and Q = Nu; or Z = COO(-) and Q = Nu(+); Q' = Nu or Nu(+)I(-); n = 0 or 1; Nu = N-heterocycle linked via S, of formula (a), (b), (c), (d) or (e); Nu(+) = N-contg. heterocycle linked through quat. N ring atom of formula (f), (g), (h) or (i); in CH2Cl2 when n = 1, or in CH2Cl2, 1,1,2-trichlorotrifluoroethane (freon TF) or 1,1,1-trichlorotrifluoroethane when n = 0, with lower alkanol (MeOH) to remove silyl gps., followed by acidification with HCl or HI, provided that when Nu(+) = 1-methyl-1-pyrrolidinio (h) and n = 0, the reaction is in Freon TF or 1,1,1-trichlorotrifluoroethane. Processes for (I) are also claimed: (i) including prepn. of the starting materials (II); and (ii) for prepn. of (I; Q = (h)) in an alternative embodiment. |
| priorityDate | 1985-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.