http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PT-78358-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba090c867801ab7bccb082f1b694ad25 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-61 |
| filingDate | 1984-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1986-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PT-78358-B |
| titleOfInvention | Chemical process |
| abstract | The present invention provides a process for preparing compounds of formula (5): NH2-AX-CH2NH2 (5) which are useful as intermediates in the preparation of compounds which are histamine H1 -antagonists. In formula (5) A is a 5-membered heterocyclic aromatic group containing up to three hetero-atoms of which no more than one can be oxygen or sulphur and from one to three can be nitrogen; a 6-membered monocyclic aromatic group optionally containing up to three nitrogen hetero-atoms or a 9- or 10-membered bicyclic aromatic group optionally containing up to four hetero-atoms, of which no more than one can be oxygen or sulphur and from one to four can be nitrogen, the group A being optionally substituted with one or more groups which are inert under the reaction conditions; X is a C1-5 alkylene group or a C2-5 alkenyle group; which comprises (a) reacting a compound of formula (6): NO2-AX-CN (6) where A and X are as defined with reference to formula (5) with hydrazine in the presence of a transition metal catalyst to form a compound of formula (7): NH2-AX-CN (7) where A and X are as defined with reference to formula (5) and thereafter (b) reacting the compound of formula (7) so obtained with more hydrazine and Raney nickel. |
| priorityDate | 1983-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.