http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PT-2084151-E
Outgoing Links
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96ec3985e3ce9b24614fb87bf51a4f12 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
filingDate | 2007-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e474b9038111d7a8f2cef04659e5688b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9d2c1e2c2fa667c68eb47b9f9ca23c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc56b6d31aeef70559c7be0916039192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_334c9ffa30c7687a91753998a4e7a9e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe47c4ba836b4c837c0fb37d8818c3ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49e71e0361759061f8f5644fb9bbb15a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8798e57ade461b74215a2a1da9a8b6db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3a2602d82a1af14832f1a4e32f368bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08dd5194a61b123cbf059343a2110d31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_272d98168fe56302af9cffab157932dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c400bd8cdacc788a9b627686fe5e9a95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_770f8de7e8042840fcc7264ccb495fcb |
publicationDate | 2013-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | PT-2084151-E |
titleOfInvention | REPLACED DI-HYDROPYZOLONES FOR THE TREATMENT OF CARDIOVASCULAR AND HEMATOLOGICAL DISEASES |
abstract | Pyrazol-3-one compounds (I) and their salts, solvates and solvate of the salts, are new, where (I) excludes 3-methyl-1-(pyridin-2-yl)-4-(1 -pyridin-2-yl-3-methyl-1H-pyrazol-5-yl)-2H-3-pyrazolin-5(1H)-one. Pyrazol-3-one compounds of formula (I) and their salts, solvates and solvate of the salts, are new, where (I) excludes 3-methyl-1-(pyridin-2-yl)-4-(1-pyridin-2-yl-3-methyl-1H-pyrazol-5-yl) -2H-3-pyrazolin-5(1H)-one. R 1>nitrogen containing aryl group of formula (a)-(d); A : C-R 4> or N, where maximum two ring members of A are simultaneously N; E : O, S or N-R 5>; R 2>nitrogen containing heteroaryl-group of formula (e)-(q); a1, a2 : point of attachment with the dihydropyrazolone ring; G : C-R 6> or N, where maximum two ring members of G are simultaneously N; J : O, S or N-R 7>; L : C-R 8> or N, where maximum two ring members of L are simultaneously N; R 4>, R 6>, R 8>H, halo, cyano, NO 2, (1-6C)-alkyl (substituted with 1-3 of T), (3-7C)-cycloalkyl, 4-7-membered heterocycloalkyl, phenyl, 5- or 6-membered heteroaryl (where the (hetero)cycloalkyl, phenyl and heteroaryl are substituted with 1-3 of T 1>), -C(=O)-R 9>, -C(=O)-R 1> 0>, -C(=O)-NR 1> 1>R 1> 2>, -O-C(=O)-R 1> 3>, -O-C(=O)-NR 1> 4>R 1> 5>, -NR 1> 6>-C(=O)-R 1> 7>, -NR 1> 8>-C(=O)-OR 1> 9>, -NR 2> 0>-C(=O)-NR 2> 1>R 2> 2>, -NR 2> 3>-SO 2-R 2> 4>, -SO 2-R 2> 5>, -SO 2-NR 2> 6>R 2> 7>, -OR 2> 8>, -SR 2> 9> or -NR 3> 0>R 3> 1>; T : halo, CN, oxo, (3-7C)-cycloalkyl, 4-7-membered heterocycloalkyl, phenyl, 5- or 6-membered heteroaryl, -C(=O)-R 9>, -C(=O)-OR 1> 0>, -C(=O)-NR 1> 1>R 1> 2>, -O-C(=O)-R 1> 3>, -O-C(=O)-NR 1> 4>R 1> 5>, -NR 1> 6>-C(=O)-R 1> 7>, -NR 1> 8>-C(=O)-OR 1> 9>, -NR 2> 0>-C(=O)-NR 2> 1>R 2> 2>, -NR 2> 3>-SO 2-R 2> 4>, -SO 2-R 2> 5>, -SO 2-NR 2> 6>R 2> 7>, -OR 2> 8>, -SR 2> 9> or -NR 3> 0>R 3> 1>, where the cycloalkyl-, heterocycloalkyl-, phenyl- and heteroaryl are substituted by 1-3 of halo, CN, (1-4C)-alkyl, trifluoromethyl, OH, (1-4C)-alkoxy, trifluoromethoxy, oxo, amino, mono-(1-4C)-alkylamino, di-(1-4C)-alkylamino, hydroxycarbonyl and/or (1-4C)-alkoxycarbonyl; T 1>(1-6C)-alkyl, halo, CN, oxo, -C(=O)-R 9>, -C(=O)-OR 1> 0>, -C(=O)-NR 1> 1>R 1> 2>, -O-C(=O)-R 1> 3>, -O-C(=O)-NR 1> 4>R 1> 5> -NR 1> 6>-C(=O)-R 1> 7>, -NR 1> 8>-C(=O)-OR 1> 9>, -NR 2> 0>-C(=O)-NR 2> 1>R 2> 2>, -NR 2> 3>-SO 2-R 2> 4>, -SO 2-R 2> 5>, -SO 2-NR 2> 6>R 2> 7>, -OR 2> 8>, -SR 2> 9> or -NR 3> 0>R 3> 1>, where the alkyl is substituted with 1-3 of halo, CN, OH, trifluoromethoxy, (1-4C)-alkoxy, amino, mono-(1-4C)-alkylamino, di-(1-4C)-alkylamino, hydroxycarbonyl, (1-4C)-alkoxycarbonyl, (3-7C)-cycloalkyl, 4-7-membered heterocycloalkyl, phenyl or 5- or 6-membered heteroaryl; either R 9>-R 1> 1>, R 1> 3>, R 1> 4>, R 1> 7>, R 1> 9>, R 2> 1>, R 2> 4>, R 2> 5>, R 2> 6>, R 2> 8>-R 3> 0>H, (1-6C)-alkyl (substituted with 1-3 of halo, cyano, OH, trifluoromethoxy, (1-4C)-alkoxy, amino, mono-(1-4C)-alkylamino, di-(1-4C)-alkylamino, hydroxycarbonyl, (1-4C)-alkoxycarbonyl, (3-7C)-cycloalkyl, 4-7-membered heterocycloalkyl, phenyl or 5- or 6-membered heteroaryl), (where the (hetero)cycloalkyl, phenyl and heteroaryl are substituted with 1-3 of halo, cyano, (1-4C)-alkyl, trifluoromethyl, OH, (1-4C)-alkoxy, trifluoromethoxy, oxo, amino, mono-(1-4C)-alkylamino, di-(1-4C)-alkylamino, hydroxycarbonyl or (1-4C)-alkoxycarbonyl); and R 1> 2>, R 1> 5>, R 1> 6>, R 1> 8>, R 2> 0>, R 2> 2>, R 2> 3>, R 2> 7>, R 3> 1>H or (1-6C)-alkyl, which is optionally substituted with halo, CN, OH, trifluoromethoxy, (1-4C)-alkoxy, amino, mono-(1-4C)-alkylamino, di-(1-4C)-alkylamino, hydroxycarbonyl or (1-4C)-alkoxycarbonyl; or R 1> 1>R 1> 2>, R 1> 4>R 1> 5>, R 1> 6>R 1> 7>, R 1> 8>R 1> 9>, R 2> 0>R 2> 1>, R 2> 1>R 2> 2>, R 2> 3>R 2> 4>, R 2> 6>R 2> 7>, R 3> 0>R 3> 1>5- or 6-membered heterocycloalkyl ring; R 5>, R 7>H, (1-6C)-alkyl (substituted by T), (3-7C)-cycloalkyl, 4-7-membered heterocycloalkyl, phenyl and 5- or 6-membered heteroaryl (where the (hetero)cycloalkyl, phenyl and heteroaryl are substituted with 1-3 of T 1>); and R 3>H, (1-6C)-alkyl or (3-7C)-cycloalkyl. Independent claims are included for: (1) preparations of (I); and (2) a medicament comprising (I) and inert, non-toxic auxiliary material. [Image] [Image] [Image] [Image] - ACTIVITY : Cardiant; Antianemic; Nephrotropic; Antianginal; Cerebroprotective; Vasotropic; Antiarteriosclerotic; Hypotensive; Dermatological; Antimicrobial; Antiinflammatory; Gastrointestinal-Gen; Antiarthritic; Antirheumatic; Ophthalmological; Antiparkinsonian; Neuroprotective; Nootropic; Analgesic; Vulnerary; Anabolic; Endocrine-Gen; Antidiabetic. - MECHANISM OF ACTION : Hypoxia-inducible transcription factor (HIF)-prolyl-4-hydroxylase inhibitor. |
priorityDate | 2006-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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