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publicationDate 2015-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber PT-106738-B
titleOfInvention METHOD FOR THE CONTROL OF OSTWALD DIFUSIONAL DEGRADATION PHENOMENON (OSTWALD RIPENING) IN THE PROCESSING OF PARTICLES OF A PHARMACEUTICAL INGREDIENT
abstract The present invention relates to a process for monitoring OSTWALD RIPENING DIFFUSION DEGRADATION PHENOMENA, OCCURRING IN PARTICLE SUSPENSIONS, WITHOUT THE NEED FOR ADDITION OF STABILIZING AGENTS, THROUGH THE USE OF HIGH PRESSURE HOMOGENIZATION UNDER PRESSURE CONDITIONS MODIFIED SO THAT NO INCREASE OR DECREASE OF THE PARTICLE SIZE OCCURS, ALLOWING THE STABILIZATION OF THE SUSPENSION DURING THE STEP OF INSULATION OF THE PARTICLES IN THE FORM OF A DRY POWDER.
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