http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PT-100993-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a717ea5b2ac78ac329ab3a9659d834d2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-80 |
| filingDate | 1992-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba8831e5f2fcb1e014bff7a3f6a2f821 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4b4e9325feb04074b1a8e4257f73ca2 |
| publicationDate | 1999-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PT-100993-B |
| titleOfInvention | SUBSTITUTED HETEROCYCLES, NITUALLY DERIVED FROM QUINAZOLIN, PROCESS FOR PREPARING AND USING THEM |
| abstract | There are disclosed compounds of the general formula I: <IMAGE> I wherein A is -CR7=CR8-; Z is -CR7=CR8-; X is H, NR 9R10, OR11, CN, F, Cl, I, Br, perfluoroalkyl, alkyl,alkoxy, alkyl-OH, alkoxyalkyl, -(CH2)nCO2R11,-(CH2)nCONR9R10; Y is NR13,NR13CR12R14, CR12R14NR13; R1 is 5-tetrazolyl, CO2R11,SO3H, NHSO2CH3, NHSO2CF3; R2,R3,R4,R7R8 is H, alkyl, alkoxy, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl, CN, NO2, SO2R13, -(CH2)nCO2R11,-(CH2)nCONR9R10, OR11,F,Cl,Br,I,NR9R10; R5 is alkyl, alkoxy, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl, H, -CN, NO2, SO2R13,-(CH2)nCO2R11, -(CH2)nCONR9R10, -OH,OR11,F,Cl,Br,I,NR9R10; R9,R10 is H, alkyl, alkoxyalkyl,alkyl-OH, perfluoroalkyl, aralkyl; R11 is H, alkyl, aralkyl, alkoxyalkyl; R12,R14 is H, alkyl, alkoxy, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl, CN, NO2, SO2R13, -(CH2)nCO2R11, -(CH2)nCONR9R10; R13 is H, OR11, alkyl, perfluoroalkyl, aralkyl, -(CH2)nCO2R11,-(CH2)nCONR9R10; wherein alkyl is defined as 1-8 carbons, branched or straight chain; perfluoroalkyl is defined as 1-6 carbons; aralkyl is defined as 7-12 carbons or 7-12 carbons substituted with fluorine, bromine or chlorine and the phamaceutically acceptable salts, solvates and hydrates thereof, which by virtue of their ability to antagonize angiotensin II are useful for the treatment of hypertension and congestive heart-failure. The compounds are also useful for reducing lipid levels in the blood plasma and are thus useful for treating hyperlipidemia and hypercholesterolemia. Also disclosed are processes for the production of said compounds and pharmaceutical compositions containing said compounds. |
| priorityDate | 1991-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 186.