| abstract |
Peptide cpds. of formula X-X1-X2-X3-L-Ser-L -Tyr-Xc-L-Pro-X10 (I) are new, in which X is naphthoyl, naphthyl propionyl, benzoyl or 1-7C acyl, X1 is D-(1)-Nal, D-(2)-Nal, D-Phe, D-(4Y)-Phe, D-(3)-Qal or a direct bond. Y is F, Br or Cl, X2 is D-Phe, D-(4Y)-Phe or a direct bond, X3 is D-Trp, D-Phe, D-(4Y)-Phe, D-(3)-Dal, D-(2)-Nal or a direct bond, X6 is D-Cit, D-Hcl, D-Orn, D-Lys or D-Neu, X8 is L-Orn, L-Arg, L-Lys, or L-Neu. At least one of X6 and X8 is D-Ala-NH2, Gly-NH2, azaglycine, -NHEt or -NHCONH2, in which Neu is a gp. of formula (II), and Z is -CH2; -CO-, =CH(OH), -O-, -S-, =SO, =SO2, =NR, or -NCOR2. |