http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-438132-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aff6633139e8f79659a0587cc38a6c07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_92372bcefb0073dd236f752c73f2eed2 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-68 |
| filingDate | 2021-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19cb2cdeb7b4d0d522cfde2359632e03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3f111993ff99f76de7da2b52a8739e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f2e9c7873f4be9ff82f0a657214942a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db31cf823fbf805be551e4af5609094d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e41a48c73325a142afa3c0ef136f3842 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11010749bbd0a12fefa16e69608b5c6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8616e746c04755ab9e2f7df012b067b |
| publicationDate | 2022-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-438132-A1 |
| titleOfInvention | Substituted derivatives of 3-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole, method for their preparation and their use |
| abstract | The subject of the invention are 3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives of the general formula 1, where R is hydrogen and X 4-aza or R is hydrogen and X 5-aza or R is hydrogen and X 6-aza or R is hydrogen and X 7-aza or R is 4-fluoro and X is CH or R is 7-fluoro and X is CH or R is 5-nitro and X is CH or R is 6-nitro and X is CH or R is 6-methyl and X is CH or R is 7-methyl and X is CH. The compounds of the invention are obtained by reacting indole derivatives with 1-benzylpiperidin-4-one preferably in methanol or ethanol in the presence of potassium hydroxide. The reaction is carried out for 18 hours at the reflux temperature of the solvent. The reaction mixture is poured into deionized water and allowed to crystallize freely for 48 hours or cooled to give a precipitate on cooling. The reaction product is purified by washing with water, methanol, ether and recrystallized from a suitable solvent, preferably methanol or DMF, or purified by chromatographic methods, preferably by column chromatography (silica gel, gradient 2-5% anhydrous NH<sub>3</ sub> in MeOH/DCM). Multitarget monoamine ligand compounds, in particular the dopamine D<sub>2</sub> and serotonin 5-HT<sub>1A</sub> and 5-HT<sub>2A</sub> receptors, for use in the treatment of mental illnesses, in particular schizophrenia, bipolar disorder and depression. |
| priorityDate | 2021-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.