| abstract |
The application discloses aminotriazole compounds substituted with a piperidinyl ring which is itself substituted with a heterocyclic ring. These compounds are mammalian acid chitinase inhibitors. Also disclosed are methods of using the compounds to treat asthmatic reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurological diseases, metabolic diseases, liver disease, Stein and Leventhal syndrome, endometriosis, and cancer. The application also relates to a pharmaceutical composition and a pharmaceutically acceptable carrier and a method of inhibiting mammalian acid chitinase in a cell or tissue. |