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filingDate 2014-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc2d4034db269885300518489aab663f
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publicationDate 2015-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber PL-407949-A1
titleOfInvention A lipid composition for producing an antibody-directed liposome carrier for genetic drugs and its use
abstract The present invention relates to a lipid composition for producing an antibody-directed carrier of genetic drugs in the form of asODN, siRNA, miRNA, ribozyme RNA and DNazym, characterized in that it contains from 35.2% to 45.7% by weight of phosphatidylcholine (PC) , from 12.3% to 19.1% by weight of dioleylphosphatidylethanolamine (DOPE), from 4.9% to 6.4% by weight of 3ß-N-dimethylethanecarbamoyl cholesterol (DC-CHOL), from 10.7% to 16.6% by weight DSPE-PEG, from 4.6% to 6.2% by weight of the maleimide derivative DSPE-PEG (DSPE-PEG-Mal) and from 10.6% to 25.7% by weight of 1,2-dioleylpropane trimethylamine salt (DOTAP) and its use.
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