http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-407333-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e0e5758beac6606078f25827ec2e02f0 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-116 |
| filingDate | 2014-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_009b6124aec74dea20e0dde646bdf7ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dae097c1ed08f19c26a07fc89e7d35ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76d93cf61fd31218fc0b9aab74835a87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a820e8b5c9923228742a3fae2282c2e |
| publicationDate | 2015-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-407333-A1 |
| titleOfInvention | Piperidine derivatives of 9,10-anthraquinone and the method of obtaining piperidine derivatives of 9,10-anthraquinone |
| abstract | The invention relates to a group of cytostatic antibiotics that inhibit cell division with antitumor activity and a new method for their preparation. They are based on 9,10-anthraquinone derivatives containing a heterocyclic system in the form of piperidine. Piperidine derivatives of 9,10-anthraquinone are characterized by the fact that they are 1- (piperidin-1-yl) -9,10-anthraquinone of the general formula (1) containing in its structure a piperidine ring in position 1 of the 9,10-anthraquinone ring . The method of obtaining the piperidine derivative of 9,10-anthraquinone is that 1-chloro-9,10-anthraquinone, or 1-fluoro-9,10-anthraquinone, or 1-tosyloxy-9,10-anthraquinone is used as the starting material. in which the reaction is carried out in a tolueu environment, or in an isopropanol environment or in an ethanol environment, heating the reaction mixture to 80 ° C for about 24 hours, after which the compounds obtained after the reaction are washed with process water (chemically and bacteriologically inactivated) . The organic layer obtained is dried in anhydrous MgSO4, after which the thus obtained crude intermediate is isolated on silica gel using methylene chloride and methanol (5: 0.1) as the eluent, resulting in a piperidine derivative of 9.10 - anthraquinone in yield about 90%. |
| priorityDate | 2014-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.