http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-403324-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47c7bbe952d2db7a86a178db094082b0 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D419-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-06 |
| filingDate | 2013-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a163d7a4005d8d24fd16e4fdb5bda49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3745a07ac14b604f8c9d8c9eb0d11b99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d475ad5bae5902092406988fecc48f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0443957ec0485df821a5c155c9bdc27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62f26c7a48f2c9339cd7c7f30d86ee69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d1348d39016a6853a3e38703cc8f850 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1ea240b04ad3541a7bc7829c06a6a89 |
| publicationDate | 2014-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-403324-A1 |
| titleOfInvention | 3,5-disubstituted and 3,4,5-tri-substituted isoxazoles and the method of their preparation |
| abstract | The subject of the invention are 3,5-disubstituted and 3,4,5-trisubstituted isoxazoles of the general formulas 1a, 1b, 1c and 1d, where: Ar - is a substituted mono- or polynuclear aryl group, in particular 2,4-dichlorophenyl, 2 ,4-dibromophenyl, 2,4-difluorophenyl, 2,6-dichlorophenyl, 2,4-dimethylphenyl, 2,4-dimethoxyphenyl, 3,4-methylenedioxyphenyl, 2,6-dimethylphenyl, 2,6-difluorophenyl, 2,4 ,6-trimethylphenyl, 2,4,6-trimethoxyphenyl, 9-anthracenyl; Q - is a sterically built, substituted or unsubstituted, mono- or polynuclear aryl group, in particular 2,2'-bitiophen-5-yl, 9-anthracenyl, 1-naphthyl; A - is a linker in the form of a difunctional aryl or heteroaryl group, in particular 1,2-phenylene, 1,3-phenylene, 1,4-phenylene, anthracene-9,10-diyl. The invention also includes a method for their preparation in dipolar cycloaddition reactions of aromatic nitrile oxides or aromatic dinitrile dioxides to mono- and symmetrically disubstituted alkynes, in solvents such as short-chain alcohols, diethyl ether, saturated haloalkanes, acetone or preferably methylene chloride or any mixtures thereof. The substrates of these reactions are low-reactive dipoles and sterically developed dipolarophiles. The reactions are carried out under high pressure, from 0.5 to 2.0 GPa, at a temperature from 10 to 110°C, for 1 to 48 hours, in an inert gas atmosphere, preferably argon. Compounds obtained in this way can be used, among others, as pharmaceuticals, substrates for further syntheses or precursors of nanomaterials for organic electronics. |
| priorityDate | 2013-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.