| abstract |
The insulin analogue or its pharmaceutically acceptable salt containing two polypeptides forming the A chain and the B chain is characterized by the general formula 1, where X is the basic amino acid and is lysine or arginine, and R is the neutral amino acid selected from glycine, alanine , serine or threonine, wherein the amino acid sequence of the A chain is selected from SEQ ID No. 1 to 4, while the amino acid sequence of the B chain is selected from SEQ ID No. 5 or SEQ ID No. 6, and that the insulin analogue has an isoelectric point from 6 to 8. The invention also includes a sustained therapeutic pharmaceutical composition, use of an insulin analogue, dosing regimen and method of treating diabetes. The solution refers to compounds that are stable insulin, pharmacologically active, characterized by prolonged, flat, peakless glucose concentration during repeated administration and not showing strong daily fluctuations in glucose concentration, i.e. saw teeth effect. |