http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-397971-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aea792dd2136d9f7abad4cba87c255ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_92372bcefb0073dd236f752c73f2eed2 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-12 |
| filingDate | 2012-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9b0360edafd88e60f9019625b021db0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0cec9064f031eaf0b3d2bce26623a1a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6676c226fcbff918e16457ef1efc5171 |
| publicationDate | 2013-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-397971-A1 |
| titleOfInvention | 5- (4-Chloro-phenyl) -4- (2,4-difluorophenyl) -2,4-dihydro-3H-1,2,4-triazol-3-thion derivative, method of its preparation and its first medical application |
| abstract | A 1,2,4-triazole derivative of general formula 1 is described, which is 5- (4-chlorophenyl) -4- (2,4-difluorophenyl) -2,4-dihydro-3H-1,2,4-triazole Anticonvulsant 3-thionium and method of obtaining 5- (4-chlorophenyl) -4- (2,4-difluorophenyl) -2,4-dihydro-3H-1,2,4-triazole-3-thione of general formula 1 , in which the 4-chlorobenzoic acid hydrazide of formula II is reacted with 2,4-difluorophenyl isothiocyanate of formula 3, the reactions being carried out in a 1: 1 molar ratio, in polar solvents, at the boiling point of the solvent. The reaction mixture is cooled to room temperature and the resulting product 1 - [(4-chlorophenyl) carbonyl] -4- (2,4-difluorophenyl) thiosemicarbazide of formula 4 is filtered off, dried and crystallized from a suitable polar solvent, preferably from ethanol. It then cyclizes in an aqueous hydroxide solution at the boiling point of the solvent, and after cooling the solution is mixed with an aqueous acid solution. |
| priorityDate | 2012-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.