http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-396648-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42cfef3e1867f4ce3651e0d700295680 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-215 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-661 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 |
| filingDate | 2011-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4979524b8e83eddad443e97b6651d05c |
| publicationDate | 2013-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-396648-A1 |
| titleOfInvention | Pharmaceutical form containing a therapeutically effective amount of (3R, 4R, 5S) -4- (acetylamino) -5-amino-3- (1-ethylpropoxy) cyclohex-1-ene-1-carboxylic acid ethyl ester and a method for its preparation |
| abstract | The pharmaceutical form containing a therapeutically effective amount of the monoaddition salt of (3R, 4R, 5S) -4- (acetylamino) -5-amino-3- (1-ethylpropoxy) cyclohex-1-ene-1-carboxylic acid ethyl ester with phosphoric acid (V ), hereinafter referred to as the active substance, according to the invention is characterized in that it is a hard capsule containing the active substance in granular form in an amount of at least 43 to 49% by weight based on the total weight of the hard capsule. The invention also relates to a process for the preparation of the pharmaceutical form as defined above, which consists in the fact that the active substance is subjected to fluidized granulation, and the resulting granulate is mixed with excipients and then encapsulated. When carrying out granulation, the active substance is placed in a fluidized bed, optionally together with a filler and a binder, and the fluidized bed is sprayed with a solution or suspension of excipients. Depending on the needs, the properties of the mixture filling the capsule are optimized by means of changes in the composition of the mixture and by modifying the production method. Modifying the production method relates to a fluid bed granulation process for the active substance. |
| priorityDate | 2011-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.