| titleOfInvention |
An isolated human antibody or antigen binding portion thereof, a pharmaceutical composition containing it, a method of inhibiting human IL-12 activity in vitro, use of the antibody or antigen binding portion thereof, a method of detecting human IL-12, isolated nucleic acid molecule, recombinant expression vector, host cell and a method of synthesizing a human antibody or antigen binding portion thereof |
| abstract |
Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the inveniton are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. |