titleOfInvention |
An isolated human monoclonal antibody binding human CD20, a transfectoma associated with this antibody, host cell, transgenic animal or plant, composition, immunoconjugate, bispecific molecule, expression vector, pharmaceutical composition, medical use, kit and anti-idiotypic antibody and its use |
abstract |
Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies. |