| abstract |
The present invention provides a compound represented by the formula:n wherein R 1 is a C 1-4 alkyl; R 2 is (1) a 5- to 7-membered nitrogen-containing heterocyclic group which may have a substituent selected from the group consisting of (1') a halogen, (2') a hydroxy group, (3') a C 1-4 alkyl and (4') a C 1-4 alkoxy, (2) a phenyl which may have a substituent selected from the group consisting of (1') a halogen, (2') a C 1-4 alkoxy-C 1-4 alkyl, (3') a mono-C 1-4 alkyl-carbamoyl-C 1-4 alkyl, (4') a C 1-4 alkoxy and (5') a mono-C 1-4 alkylcarbamoyl-C 1-4 alkoxy, or the like; R 3 is a C 1-4 alkyl; R 4 is a C 1-4 alkoxy, or the like; n is an integer of 1 to 4; or a salt thereof, as a thienopyrimidine compound having gonadotropin-releasing hormone antagonistic activity. |