http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-213967-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2901e694724c2a759f619944cb7d2a4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-84 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-84 |
| filingDate | 2003-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ee0a9e8ed48a9c2cecc1f40e66ff7bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7c6e0ddee000ce3bda43da927a712f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9abcba58a3cf40dde18a7a290977ab16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd9c5c5a3a358f5fe35fc43fb82829c9 |
| publicationDate | 2013-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-213967-B1 |
| titleOfInvention | Production method of combrestins and an indirect compound |
| abstract | Preparation of combrestatins (I) by a Wittig condensation of (3,4,5-trimethoxybenzyl) triphenyl phosphonium bromide or chloride with 3-nitro-4-methoxy benzaldehyde, or of 3,4,5-trimethoxy benzaldehyde with a (4-methoxy-3-nitrobenzyl) triphenyl phosphonium salt, followed by reduction of the nitro group on the product in the presence of iron. Preparation of combrestatins (I) by a Wittig condensation of (3,4,5-trimethoxybenzyl) triphenyl phosphonium bromide or chloride with 3-nitro-4-methoxy benzaldehyde, or of 3,4,5-trimethoxy benzaldehyde with a (4-methoxy-3-nitrobenzyl) triphenyl phosphonium salt, followed by reduction of the nitro group on the product in the presence of iron. [Image] A' : an amino group. Independent claims are included for (1) the process as described but in which the nitro group in the starting material is replaced by an amino group; (2) preparation of 2-amino-3-hydroxy-N-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenyl}-propionamide hydrochloride salt of formula (IV) by reacting (I; A = NH 2) with a protected cyclic derivative of serine of formula (IIb), to give an intermediate (III) followed by removal of the protecting group PG; (3) intermediates of formula (III). [Image] [Image] PG : a protecting group such as tert. butoxycarbonyl, benzyloxy carbonyl, or 9-fluorenylmethyloxy carbonyl. ACTIVITY : Cytostatic. MECHANISM OF ACTION : Not given in source material. |
| priorityDate | 2002-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 108.