http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-211491-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6572ff5df928fd17340eb2a8cb6d8502 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06026 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0222 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 |
| filingDate | 2004-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5c79ee99565f9ce4e0f3c7c073f9c14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a0c70dd32466b232c55b736c15671c3 |
| publicationDate | 2012-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-211491-B1 |
| titleOfInvention | The method of obtaining perindopril and its pharmaceutically acceptable salts |
| abstract | Process for the industrial preparation of perindopril (I) and its salts by reaction of N-((S)-carbethoxy-1-butyl-(S) alanine (II) with a carbonyl derivative (III) to form a dioxo oxazolidine derivative (IV). This is reacted with an indole-2-carboxylic acid derivative (V) to form an unsaturated perindopril derivative (VI). This is hydrogenated in the presence of a catalyst to form (I). Process for the industrial preparation of perindopril (I) and its salts by reaction of N-((S)-carbethoxy-1-butyl-(S) alanine (II) with a carbonyl derivative (III) to form a dioxo oxazolidine derivative (IV). This is reacted with an indole-2-carboxylic acid derivative (V) to form an unsaturated perindopril derivative (VI). X1, X2 = leaving groups, especially Cl, imidazolyl, or trichloromethoxy; and R = H, benzyl, or 1-6C alkyl. This product is hydrogenated in the presence of a catalyst and the esterifying group is removed if necessary, to form (I). |
| priorityDate | 2003-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.