http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-205724-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/H01L21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 |
| filingDate | 2001-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c75f07838a8a23c74523afb6436a2ab3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fab9bd5f2956a73ab96a12ae41662b6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcdefeccbb19703e609c591b5f35f7d9 |
| publicationDate | 2010-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-205724-B1 |
| titleOfInvention | Method for producing citalopram |
| abstract | The present invention relates to a method for the preparation of purified citalopram of formula <CHEM> by removal of desmethyl citalopram having the formula <CHEM> comprising optionally subjecting a crude citalopram product containing the desmethyl citalopram impurity to some initial purification and subsequently treating the crude product with an amide or an amide-like group forming agent selected from the agents of Formulas (a), (b) or (c): <CHEM> where X is halogen or a group O-CO-R', Hal is halogen, Y is O or S, W is O, N or S and R, R', R" and R'" are each selected from the group consisting of hydrogen, alkyl, and optionally substituted aryl or aralkyl; the reaction mixture is then subjected to an acid/base wash and/or crystallisation and recrystallisation of citalopram in order to remove the amides formed from the crude citalopram mixture; and the resulting citalopram product is optionally further purified, worled up and isolated as the base or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2000-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.