http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-204819-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71b944100daf03103e6704d7474fd127 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-46 |
| filingDate | 2001-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_394e8b93704815c08b8dce51624976dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43664f7743bdc553812493117748e5f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29e02bd7a3ba651fb676ef8136e19329 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_323e6f5fdac2f8ea4a12f96b70873235 |
| publicationDate | 2010-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-204819-B1 |
| titleOfInvention | Production method of (S) -N, N'-bis [2-hydroxy-1- (hydroxy-methyl) ethyl] -5 - [(2-hydroxy-1-oxopropyl) amino] -2,4,6-triiodo 1,3-benzenodikarboksyamidu |
| abstract | A process for the preparation of <i>(S)-N,N'</i>-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide (iopamidol) starting from 5-amino-<i>N,N'</i>-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-1,3-benzenedicarboxamide (II) which process comprises a) reacting the compound of formula (II) with a suitable protecting agent, to give a compound of formula (III) wherein R is a group of formula A or B wherein R1 is a hydrogen atom, a C1 DIVIDED C4 straight or branched alkoxy group, R2 is hydrogen, a C1 DIVIDED C4 straight or branched alkoxy group and R3 is a C1 DIVIDED C4 straight or branched alkyl group, a trifuoromethyl or a trichloromethyl group; b) acylating the amino group in position 5 of the intermediate compound of formula (III), by reaction with a (S)-2-(acetyloxy)propanoyl chloride to give a compound of formula (IV) wherein R is as defined above; and c) removing all the acyl groups present in the compound of formula (IV) under basic conditions, with prior cleavage of the cyclic protections of the hydroxy groups in the carboxamido substituents under acidic conditions, when R is a group of formula A carboxamido hydroxy groups under acidic conditions. The invention also refers to the new intermediates of formula (III) and (IV) wherein -R is a group A. |
| priorityDate | 2000-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.