abstract |
This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula (I) wherein one of X, Y or Z is independently -S-,-0- CH2- or >N-R<6>, the others are -CH2-; m is an integer from 0 to 3 inclusive; n is an integer from 1 to 6 inclusive; R<4> is (C1-6)-alkyl; R<5> is independently in each occurrence (C1-6)-alkyl, (C1-6)-alkenyl, (C1-6)- alkynyl or cycloalkyl; and R<1>, R<2>, and R<3> are hydrogen or specified substituents. These compounds are useful for treating diseases associated with smooth muscle disorders. |