http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-202856-B1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25b4c357a0855789b0f8efa9273220f1 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
filingDate | 2002-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16ab1e75205363f25a1fcd3f1eb3a642 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2e5fbc8c70da1981a5ab1ad2b268184 |
publicationDate | 2009-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | PL-202856-B1 |
titleOfInvention | Method for obtaining the pharmaceutically pure polymorphic form I olanzapine |
abstract | The present invention relates to a process for the preparation of pharmaceutically pure polymorphic form I of olanzapine, which com-prises crystallization of olanzapine from a solution in methylene chlo-ride, wherein before the crystallization, said solution of olanzapine in methylene chloride is treated with silica gel, preferably at reflux tem-perature. Also disclosed is form I of olanzapine substantially free of im-purity S, as well as a process for removing of impurity S from olanzap-ine polymorphic form I. |
priorityDate | 2002-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.