http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-202856-B1

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classificationCPCAdditional http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04
filingDate 2002-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16ab1e75205363f25a1fcd3f1eb3a642
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2e5fbc8c70da1981a5ab1ad2b268184
publicationDate 2009-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber PL-202856-B1
titleOfInvention Method for obtaining the pharmaceutically pure polymorphic form I olanzapine
abstract The present invention relates to a process for the preparation of pharmaceutically pure polymorphic form I of olanzapine, which com-prises crystallization of olanzapine from a solution in methylene chlo-ride, wherein before the crystallization, said solution of olanzapine in methylene chloride is treated with silica gel, preferably at reflux tem-perature. Also disclosed is form I of olanzapine substantially free of im-purity S, as well as a process for removing of impurity S from olanzap-ine polymorphic form I.
priorityDate 2002-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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