http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-198648-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_00f26822cfc3af7bd1194f6e44f82033 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-89 |
| filingDate | 2002-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_010018738f8a416ea51f2e1fe39b2667 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b192730384596e0d36ba22855061a55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ada86d5878e9ffbe6fdfc23073a48b35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a7f45c78763389911730b37d826c9a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_086ed46716e02a8ab3818306211baa6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f794f64dd4ebf60e57cabfa85da47b5f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccb65f7e9e9f33cf9ccf57694c8fbaba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25ecc8a06f2220643b2a2947a9328fa4 |
| publicationDate | 2008-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-198648-B1 |
| titleOfInvention | The method of obtaining a benzaldehyde derivative and its salts and new intermediates |
| abstract | CLAIMS 1. A process for the preparation of a benzaldehyde derivative of formula I or a salt thereof with hydrochloric, formic or acetic acid comprising the steps of preparing 2-ethoxy -5- (4-methylpiperazinyl-1-sulfonyl) benzoic acid alkyl ester, 2-ethoxy-acid hydrazide 5- (4-methylpiperazinyl-1-sulfonyl) benzoic acid and its sulfonyl derivative and its conversion to the benzaldehyde derivative of formula 1, characterized in that 2-ethoxybenzoic acid of formula 2 is esterified with an aliphatic alcohol of the general formula 3, in which R is a chain containing a maximum of 6 methylene and methyl groups, separated by an oxygen atom, in the presence of thionyl chloride, and then the reaction mixture is added to water, the halogenated hydrocarbon derivative is extracted, the extract washed e with sodium hydrogen carbonate solution and water, followed by concentration, and the resulting 2-ethoxybenzoic acid ester of general formula 4, in which R is the same as given in formula 3, d it is poured into chlorosulfonic acid at a reduced temperature, then stirred, the resulting reaction mixture is added to water, and the obtained aqueous solution is extracted with a halogenated hydrocarbon derivative, the extract washed with water and concentrated, and the resulting acid ester is extracted 2-ethoxy-5-chlorosulfonylbenzoic acid of general formula 5, in which R is the same as given in formula 3, is dissolved in acetone and added to an acetone solution containing triethylamine e and N-methylpiperazine e, and then mixed The precipitate is filtered off, the filtrate is filtered, dissolved in a halogen derivative in aliphatic hydrogen, washed with water and concentrated, the obtained ester of 2-ethoxy-5- (4-methylpiperazinyl-1-sulfonyl) benzoic acid of the general formula 6 , in which R is the same as given in formula 3, is reacted ……………………………………………………… .. EN EN |
| priorityDate | 2002-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 104.