| abstract |
Compounds of formula (I), or a salt or a non toxic metabolically labile esters thereof, wherein Y represents a carbon atom; Z is the group CH which is linked to the group Y via a double bond and X is CH or Z is methylene or NR11 and X is a carbon atom linked to the group Y via a double bond; A represents a C1-2alkylene chain and which chain may be substituted by one or two groups selected from C1-6alkyl optionally substituted by hydroxy, amino, C1-4alkyl amino or C1-4dialkyl amino or which chain may be substituted by the group =0; R represents a halogen atom or C1-4alkyl group; R1 represents a hydrogen, a halogen atom or C1-4alkyl group; R2 represents optionally substituted phenyl, a 5 membered heteroaryl group containing 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen or 6 membered heteroaryl group containing 1 to 3 nitrogen atoms, processes for their preparation and their use as glycine antagonists. |