| abstract |
The invention concerns novel camptothecin tetracyclic analogues of formula (I), preparation methods, applications as medicines and pharmaceutical compositions containing them. Said analogues, among which figures in particular 3-hydroxy-3-(4-oxo-4,6-dihydroindolizino [1,2-b] quinoline-2-yl)pentanoic acid, have a powerful biological activity for inhibiting topoisomerase I and/or topoisomerase II. |