| abstract |
Method for making padlixel of formula 1ncharacterized in that the amide of formula 2nwhere R is hydrogen or methyl and R 1 is lower alkyl.nPreferably with 1-3 carbon atoms, it is cyclized in an inert organic solvent with the aid ofnactivated benzaldehyde dimethyl acetal of formula 2a, where R2 and R3 are independently hydrogennor an alkoxy group of 1-3 carbon atoms under acidic catalysis, simultaneous removal of methanol |