| abstract |
Ultra short acting neuromuscular blocking agents of Formula (I) which are useful as skeletal muscle relaxants during emergency intubation procedures, routine surgery and post-operative settings are disclosed,n n wherein q and t are independently from 0 to 4; and X 1 and X 2 are independently halogen; h a and h b are independently from 0 to 2; Z 1 and Z 2 are independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl with the proviso that Z 1 and Z are not both hydrogen; Y 1 , Y 2 , Y 3 and Y 4 are independently hydrogen, halogen or C 1 -C 3 alkoxy; m and p are independently 1 to 6; n and r are independently 0 to 4; with the proviso that if h a and h b are both 0, then r is 0 and n is 0 to 2; R 1 and R 14 are independently hydrogen, halogen, C 1 -C 3 alkoxy, or R 2 and R 3 together with the carbon atoms to which they are bonded, R 5 and R 6 together with the carbon atoms to which they are bonded, may independently form a methylenedioxy or ethylenedioxy moiety contained in a five- or six-membered ring; W 1 and W 2 are carbon; and A is a pharmaceutically acceptable anion. |